31 days in South America, Central America & Caribbean Itinerary

31 days in South America, Central America & Caribbean Itinerary

Created using Inspirock travel route planner

Make it your trip
1
Iquitos, Peru
— 2 nights
Fly
2
Guayaquil, Ecuador
— 3 nights
Fly
3
Cali, Colombia
— 1 night
Fly
4
Bogota, Colombia
— 4 nights
Fly
5
Medellin, Colombia
— 4 nights
Fly
6
Panama City, Panama
— 5 nights
Fly
7
Cartagena, Colombia
— 3 nights
Drive
8
Barranquilla, Colombia
— 2 nights
Fly
9
Oranjestad, Aruba
— 6 nights

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Iquitos, Peru

— 2 nights

Capital of the Peruvian Amazon

The largest city in the Peruvian Amazon and the world's largest metropolis unreachable by road, Iquitos represents a major starting point for river and rainforest adventures.
Kick off your visit on the 2nd (Sun): identify plant and animal life at Wildlife Areas.

To see other places to visit, ratings, maps, and tourist information, read Iquitos road trip planning website.

Expect a daytime high around 37°C in May, and nighttime lows around 26°C. Cap off your sightseeing on the 3rd (Mon) early enough to travel to Guayaquil.

Things to do in Iquitos

Wildlife · Tours · Outdoors
Highlights from your trip

Guayaquil, Ecuador

— 3 nights

Pearl of the Pacific

Hills dotted with colorful houses and waterfront promenades typify Guayaquil, Ecuador's largest city and commercial center.
Guayaquil is known for historic sites, parks, and shopping. Your plan includes some of its best attractions: explore and take pictures at Guayaquil Historical Park, don't miss a visit to Captain Morgan's Pirate Ship, take in nature's colorful creations at Parque Seminario, and take in panoramic vistas at La Perla.

To find where to stay, photos, more things to do, and tourist information, use the Guayaquil trip planner.

You can fly from Iquitos to Guayaquil in 8 hours. Alternatively, you can do a combination of car, ferry, and bus; or do a combination of ferry and bus. In May, daily temperatures in Guayaquil can reach 36°C, while at night they dip to 27°C. Wrap up your sightseeing on the 6th (Thu) to allow time to travel to Cali.

Things to do in Guayaquil

Historic Sites · Neighborhoods · Parks · Wildlife

Cali, Colombia

— 1 night

Salsa Capital of the World

Learning how to salsa may be the most popular thing to do in Cali, but this giant city in southwestern Colombia represents more than just the "Salsa Capital of the World." Home to over 2 million people, thriving Cali serves as a major commercial and industrial center in South America, boasting the fastest-growing economy in Colombia.
On the 6th (Thu), see the interesting displays at Museo del Oro Calima and then hike along Picoloro Ecoturismo. Here are some ideas for day two: see the interesting displays at MUSA Museo Arqueologico, then admire the masterpieces at Museo de Arte Colonial y Religioso La Merced, then pause for some photo ops at Cristo Rey, and finally see the interesting displays at Caliwood Museo de la Cinematografia.

To see maps, other places to visit, reviews, and tourist information, you can read our Cali online travel route builder.

You can fly from Guayaquil to Cali in 4.5 hours. Other options are to drive; or take a bus. Traveling from Guayaquil in May, plan for little chillier nights in Cali, with lows around 22°C. Cap off your sightseeing on the 7th (Fri) early enough to travel to Bogota.

Things to do in Cali

Wildlife · Museums · Parks · Tours

Bogota, Colombia

— 4 nights

Athens of South America

Colombia's heart and soul, Bogota has earned the nickname "Athens of South America" thanks to its abundance of universities, libraries, and lower-level schools.
You'll find plenty of places to visit near Bogota: Zipaquira (Casa Museo Quevedo Zornoza & Catedral de Sal de Zipaquira) and Vivero Crisalide (in Chia). Next up on the itinerary: examine the collection at Gold Museum (Museo del Oro), stroll around Parque de Usaquen, take in the awesome beauty at Monserrate, and steep yourself in history at Bolivar Square.

Before you visit Bogota, use our trip planner to discover what you can do and see there.

Traveling by flight from Cali to Bogota takes 4 hours. Alternatively, you can drive; or do a combination of bus and taxi. Traveling from Cali in May, things will get a bit cooler in Bogota: highs are around 22°C and lows about 11°C. Finish up your sightseeing early on the 11th (Tue) so you can travel to Medellin.

Things to do in Bogota

Museums · Tours · Historic Sites · Parks

Side Trips

Medellin, Colombia

— 4 nights

City of the Eternal Spring

Nestled between rising hills in a narrow valley, Medellin serves as an energetic melting pot of people from all socio-economic classes.
Medellin is known for parks, museums, and zoos & aquariums. Your plan includes some of its best attractions: get the lay of the land with Walking tours, make a trip to Plaza Botero, add some adventure to your tour with Expedition Colombia, and see Off-Road Tours.

For reviews, other places to visit, more things to do, and other tourist information, read Medellin trip itinerary planning site.

Fly from Bogota to Medellin in 3.5 hours. Alternatively, you can drive; or take a bus. In May, Medellin is somewhat warmer than Bogota - with highs of 32°C and lows of 20°C. Wrap up your sightseeing on the 15th (Sat) to allow time to travel to Panama City.

Things to do in Medellin

Tours · Outdoors · Adventure · Parks

Side Trip

Panama City, Panama

— 5 nights

Dubai of Latin America

Arguably the most modern of Central American cities, Panama City boasts a shimmering skyline of glass skyscrapers.
Panama City is known for historic sites, shopping, and museums. Your plan includes some of its best attractions: don't miss a visit to Panama Canal, explore the ancient world of Panama La Vieja, stop by Cinta Costera, and explore the striking landscape of Metropolitan National Park.

To see photos, other places to visit, where to stay, and more tourist information, refer to the Panama City holiday maker app.

Fly from Medellin to Panama City in 5.5 hours. Alternatively, you can do a combination of bus, ferry, and taxi; or do a combination of bus and ferry. Plan for a bit warmer temperatures traveling from Medellin in May, with highs in Panama City at 36°C and lows at 29°C. Wrap up your sightseeing on the 20th (Thu) early enough to travel to Cartagena.

Things to do in Panama City

Parks · Historic Sites · Nature · Neighborhoods

Cartagena, Colombia

— 3 nights

City of Heroes

The site of the continent's first Spanish colony, Cartagena retains much of its colonial flavor thanks to a World Heritage-listed old town, encircled by old walls and protected by imposing fortresses.
Take a break from Cartagena with a short trip to Oceanario in Islas de Rosario, about 1h 35 min away. The adventure continues: step into the grandiose world of Castillo de San Felipe de Barajas, indulge in some personalized pampering at Volcan de Lodo El Totumo (Mud Volcano), take a tour by water with Boat Tours & Water Sports, and don't miss a visit to Plaza de Bolivar.

Plan a trip to Cartagena easily and quickly by telling Inspirock to suggest an itinerary.

Traveling by flight from Panama City to Cartagena takes 5.5 hours. Expect a daytime high around 38°C in May, and nighttime lows around 30°C. Cap off your sightseeing on the 23rd (Sun) early enough to go by car to Barranquilla.

Things to do in Cartagena

Historic Sites · Parks · Spas · Tours

Side Trip

Barranquilla, Colombia

— 2 nights

Golden Gate of Colombia

An industrial port city on Colombia's Caribbean coast, Barranquilla represents the fourth-most populous city in the country.
Kick off your visit on the 24th (Mon): stop by Todomono, then walk around Parque Paseo de la Castellana, and then have fun at Parque de Villa Santos.

Plan a trip to Barranquilla easily and quickly by telling Inspirock to suggest an itinerary.

Drive from Cartagena to Barranquilla in 2.5 hours. Alternatively, you can drive; or take a bus. In May, daytime highs in Barranquilla are 39°C, while nighttime lows are 29°C. Cap off your sightseeing on the 25th (Tue) early enough to travel to Oranjestad.

Things to do in Barranquilla

Parks · Fun & Games · Shopping

Oranjestad, Aruba

— 6 nights
When vacationing on Aruba, don't miss taking a tour of Oranjestad, the capital of the small Caribbean island.
Venture out of the city with trips to San Nicolas (San Nicolas Community Museum, Baby Beach, &more). There's lots more to do: tour the pleasant surroundings at Eagle Beach, kick back and relax at Palm Beach, visit a coastal fixture at California Lighthouse, and experience rural life at Aruba Ostrich Farm.

For ratings, maps, reviews, and tourist information, refer to the Oranjestad trip itinerary builder website.

Explore your travel options from Barranquilla to Oranjestad with the Route module. The time zone changes from Colombia Standard Time to Atlantic Standard Time, which is usually a 1 hour difference. In May, daily temperatures in Oranjestad can reach 38°C, while at night they dip to 31°C.

Things to do in Oranjestad

Parks · Outdoors · Beaches · Nature

Side Trips